AK Dash, PB Abhishek, MK Mohapatra, BK Barik, B Pradhan,
GC Behera, RC Tripathy, S Tripathy
Aims
and
Objective:
Dyslipidemia
is
associated
with 50%
of all
diabetic
people
and
contributes
to
substantial
increased
risk
(3-4
fold) of
premature,
extensive
and
accelerated
atherosclerosis
leading
to CAD,
PVD and
MI etc.
It
remains
silent
in
majority
of
patients
with
diabetes.
This
peculiarity
makes
CAD in
diabetes
the
single
most
important
cause of
premature
mortality
accounting
for
60-65%
of all
deaths.
The aims
of the
present
study
was to
determine
the
pattern
of
dyslipidemia
in
patients
of CAD
with
type – 2
DM so as
to
initiate
anti-lipidemic
therapy
for
secondary
prevention.
MATERIALS
AND
METHODS:
We
studied
100
cases of
type 2
DM with
CAD and
without
CAS
admitted
to V.S.S.
Medical
College
and
Hospital,
Burla,
Orissa.
The mean
age
group of
the
study
was
30-69
years
from
both the
sexes.
The FBS
and 2
hour
PPBG was
done by
glucose
oxidase
method
and
serum
lipid
profile
was
estimated
by
enzymatic
methods
and
compared
to study
the
pattern
of
dyslipidemia.
Results:
In the
present
study
dyslipidemia
was
found in
92% of
diabetic
patients
with LDL
hyperlipoproteinemia
in 76% (LDL
>
100mg%)HDL
dydlipidemia
in 64% (HDL
< 40
mg%),
hypertriglyceridemia
in 925
(TG >
150 mg%)
and
hypercholesterolemia
(56%) (>
200,g%).
The
lipid
profile
was
significantly
altered
in
patients
with
coronary
artery
disease
compared
to
patients
without
coronary
artery
diseases.
Conclusion:
The
major
concern
in the
present
study
highlights
the high
percentage
of LDL
and TG
dydlipidemia.
However
TC and
HDL
levels
were of
less
significance.
In the
present
study
more
than 90%
of
patients
were
smokers
and
alcoholics,
LDL
dyslipidemia
is more
significant
from
prognostic
and
therapeutic
point of
view,
hence
pharmacotherapy
in the
form of
statins
and TG
dyslipidemia
can be
brought
down by
blood
glucose
control
itself.
Glycemic
control
should
be the
first
priority
followed
by
fibric
acid
derivatives
or high
dose
statins.
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