To study
the
pentoxyfylline
as an
adjuvant
therapy
in
treatment
of
severe
falciparum
malaria
in
patients
of
sickle
cell
anaemia.
MATERIALS
AND
METHODS:
Patients
having
clinical
features
suggestive
of
severe
falciparum
malaria
(according
to WHO
guidelines)
excluding
pregnant
woman
were
investigated
for
sickling
test and
hemoglobin
electrophoresis.
Biochemical
and
haematological
investigations
e.g
hemoglobin
concentration,
total
leucocyte
count,
differential
count,
urine
for
sugar ,
albumin,
red cell
, pus
cell,
hemoglobin,
serum
for
direct
and
indirect
bilirubin,
AST,
ALT,
alkalaine
phosphatase,
urea,
creatinine,
sodium
and
potassium
were
done on
the day
of
asmission
and on 3rd
and 8th
day.
Detailed
daily
clinical
examination
was
done.
Forty
cases of
severe
falciparum
malaria
with
sickle
cell
disease
were
studied.
Twenty
cases
treated
with
quinine
and
pentoxyfylline
and
other
twenty
cases
were
treated
with
quinine
only.
RESULT:
Patients
who
received
pentoxyfylline
and
quinine
had less
duration
of
unconsciousness,
had
significant
fall of
bilirubin
concentration
as
compared
to those
received
quinine
only.
There
was no
significant
difference
in BUN
and
overall
mortality
between
the two
groups.
CONCLUSION:
This
study
shows
that
simultaneous
administration
of
pentoxyfylline
and
quinine
leads to
early
recovery
from
coma and
reduction
of serum
bilirubin
concentration
. So
pentoxyfylline
may be
useful
in
severe
falciparum
malaria
in
sickle
cell
disease.
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