SR Pattnaik, BK Barik, AK Panigrahi, P. Das, B Pradhan
AIM
OF THE
STUDY:
Microalbuminuria
is well
established
as the
earliest
detectable
marker
of
nephropathy
in
Diabetes.
Persistent
microalbuminuria
leads to
nephropathy,
cardiovascular
changes
and
other
complications.
The
present
study
was
undertaken
to
correlate
microalbuminuria
in both
type of
Diabetes
with
complications.
METHODOLOGY:
One
hundred
cases of
DM were
studied
during
the
period
of
January
2003 to
December
2003.
Urine
samples
of all
cases
were
subjected
to
boiling
test for
detection
of
albumin
(Microalbuminuria).
Negative
samples
were
subjected
to
micral
test for
microalbuminuria.
Cases
having
definite
previous
history
of
Renal,
Thyroid
and
Hepatic
disease
and
Nephrotoxic
drugs
exposure
were
excluded
from the
study.
All
cases
were
subjected
to
detailed
history,
clinical
and
laboratory
examination.
OBSERVATION:
In the
present
study
out of
36 cases
of Type
1 DM , 5
had
microalbuminuria(13.8%)
and out
of 64
cases of
type – 2
DM, 11
cases
had
microalbuminuria(17.1%).
In both
groups
there
was male
preponderance
(Type I,
17.3:7.6%;
Type 2
21.5:12.5%).
The 24
hour
protein
excretion
was 149±56.5
mg% in
microalbuminuria
cases.
The mean
systolic
blood
pressure
was 145
±19.95mm
of HG in
micral
positive
cases
compared
to 126±22.83
mm of Hg
in
negative
cases.
The mean
Blood
pressure
was
105.2±13.5mm
of Hg in
micral
positive
groups
as
compared
to 91.3±12.63
mm of Hg
in
control
group.
The FBS
and 2
hours
PGBS was
higher
in
micral
positive
groups.
The
creatinine
clearance
was 147±12.9ml/min
in
micral
group as
compared
to 126±13.10
ml/min
in
negative
groups
indicating
a
significant
increase
in GFR
in
microalbuminuria
cases.
The
serum
cholesterol
was high
i.e
202.3±34.45
mg% in
microalbuminuria
cases
indicating
association
of
dyslipidemia
specially
in Type
– 2 DM.
Peripheral
neuropathy,
retinopathy
and
cardiovascular
diseases
were
larger
in
patient
with
microalbuminuria
<100
mg/24
hours
suggesting
renal
hypertrophy
is an
early
feature
of
diabetic
renal
disease
and GFR
was more
in these
patients.
Renal
biopsy
showed
basement
membrane
thickening
in 11
cases
and
mesangial
cell
proliferation
in 9
cases.
CONCLUSION:
In the
present
study
microalbuminuria
was
correlated
with
different
complications
irrespective
of the
type of
DM the
systolic,
diastolic
and mean
blood
pressure
was
high.
Neuropathy,
retinopathy
and
cardiovascular
complications
were
more in
microalbuminuria
cases
and
directly
correlated
with the
duration
of
diseases.
Renal
hypertrophy
was an
early
feature
if
nephropathy.
Renal
hisopathology
was
found to
have a
direct
correlation
with
duration
of
disease
and
severity
of
microalbuminuria.
orissa medical,orissa doctor,
india pharmaceutical company,orissa nursing home,orissa chemist,orissa
pharmaceutical stockiest,orissa medical representative,orissa medical
college,orissa doctor clinic,orissa diagnostic center,orissa
hospital,orissa ambulance,orissa nursing training,orissa pharmaceutical
college,orissa homeopathic doctor,orissa homeopathic college,orissa
medical association,orissa health ,orissa health minister,orissa
government, government hospital,orissa private medical college,
