To study
the
hematological
changes
in
chronic
alcoholic
liver
diseases.
MATERIALS
AND
METHODS:
Thirty
chronic
alcoholic
patients
were
investigated
after
excluding
the
patients
having
pathological
diseases
of other
organs
those
altering
the
haematological
status.
All
selected
cases
had
history
of
alcohol
abuse
for more
than 5
years,
all the
haematological
parameters
were
compared
with the
duration
and
amount
of
alcohol
consumption
and the
observations
were
complied
and
discussed.
The
significance
of mean
in
comparison
to
control
was done
by using
student
unpaired
‘t’
test.
Association
of
parameters
with
amount
and
duration
of
alcohol
consumption
was made
by
calculating
correlation
coefficient.
RESULTS:
Chronic
alcoholism
was
commonly
observed
in 4th
and 5th
decades
with
median
age of
44
years.
The mean
Hb% was
9.2±1.3
gm% ,
macrocytosis
(MCV >
96fl) in
56.7% of
cases
and all
cases
were
normochromic
(MCH >27
pg and
MCHC>30%).
Raised
ESR
(86.6%),
leucopenia
(33.33%),
thrombocytopenia
(30%)
were
other
observations.
CONCLUSION:
Correlation
of
duration
of
alcohol
consumption
with
haematological
changes
revealed
a
significant
decrease
in Hb%
and
increase
in ESR
and
increase
in MCV
with the
duration
of
alcohol
consumption
5 to 10
years
and when
it is
more
than 10
years of
duration.
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