Study of
dyslipidemia
in
non-diabetic
first
degree
relatives
(F.D.R.)
of type
2
diabetes
mellitus
patients.
MATERIALS
AND
METHODS:
Forty
type –2
diabetes
mellitus
with
forty
numbers
of their
FDR were
included
in the
study.
Secondary
causes
of
dyslipidemia
were
excluded
in both
groups
by
history
taking,
clinical
examinations
and
appropriate
laboratory
tests.
Fasting
lipid
profile
comprising
of serum
cholesterol,
triglyceride
and HDL-C
were
done in
automatic
analyzer
and VLDL-C,
LDL-C
values
were
calculated
out by
using
Friedwald
equation.
OBSERVATION:
Mean
cholesterol,
triglyceride
and LDL-C
values
were
below
normal
(i.e.
cholesterol
<
200mg/dl,
triglyceride
<150mg/dl
and LDL-C
< 130
mg/dl)
but
diabetics
showed
higher
values
than FDR
and 15%
of FDR
were
having
HDL-C
values
below
normal
(i.e.
<40mg/dl
in males
and <45
mg/dl in
females)
22.5%
diabetics
and 30%
FDR were
having
cholesterol
/HDL
C-Ratio
> 5,
while
LDL-C/HDL
– C
ratio >
3.5 were
found in
12.5% of
diabetics
and 20%
of FDR (Atherogenic
ratio).
CONCLUSION:
F.D.R.
of type
2
diabetes
mellitus
patients
showed
very
high
incidence
of low
HDL-C
level,
perhaps
prevalence
of more
of
insulin
resistance
in them,
thus
predisposing
them to
atherogenic
profile
even if
they are
normoglycemic
and this
makes a
need of
creating
awareness
in them.
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