S. Bhakta, Sk Lath, SR Pattnaik, BK Barik, B Pradhan , S Tripathy, RC
Sethy
Aim
and
Objective:
Plaque
rupture,
the
commonest
cause of
acute
myocardial
infarction(AMI)
is
associated
with
raised
level of
acute
phase
reactants
like
C-reactive
protein.
CP is a
marker
of
atherosclerotic
inflammation
and
insult
of
myocardial
necrosis.
In this
study
serum
CRP
level in
AMI
pateitns
at the
time of
hospital
admission
was
correlated
with
their
subsequent
in
hospital
prognosis.
Materials
and
Methods:
In the
present
study,
61 AMI
patients
with
varied
types of
presentation
and risk
factors
were
taken.
Fifty
healthy
age and
sex
matched
volunteers
were
taken as
control.
Non-cardiac
causes,
which
can
raise
the CRP
level,
were
excluded
from
both
groups.
Blood
samples
of AMI
patients
for CRP
were
sent at
the time
of their
hospital
admission.
Other
cardiac
markers
like
CK-MB
and
troponin
I also
estimated
for
diagnostic
purpose
as well
as to
correlate
with CRP
as a
prognostic
indicator.
Patients
were
followed
up fro
complications
like LVF,
repeat
cardiac
discomfort,
arrhythmia,
cardiogenic
shock
and
death.
Observation:
Raised
level of
CRP
(8.20±3.86
ms/1 SD)
was
noted in
AMI
patients
compared
with
controls
(3±1.195
mg/1
SD).
Patients
with >6
mg/1 of
CRP
developed
more
(82.85%)
complications
like
arrythmia,
CCF,
pericarditis
and
repeat
chest
complications
(P<0.001).
11
patients
(18%)
expired
out of
them 10
had > 6
mg/1 CRP
(91%).
More
complications
observed
when CRP
levels
were
raised
within 6
hr
duration
of
symptoms
(70.83%).
In
contrast
to it
other
cardiac
markers
(CK-MB
and TROP
– I)
failed
to
predict
the
prognosis
within 6
hr
duration
of
symptoms.
After 6
hours ,
prognostic
value of
CRP and
other
cardiac
markers
correlated
well.
Conclusion:
The
serum
CRP
level on
hospital
admission
is an
indicator
short
term of
prognosis
of AMI
irrespective
of the
duration
of
symptoms.
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